Clio Daily supplies key mitochondrial micronutrients and a smart combination of alpha lipoic acid, N-acetyl cysteine, and acetyl L-carnitine to boost cellular energy production.

Clio Bladder:

• Recharges Cellular Energy Production
• Supports Immune Function
• Increases Antioxidant Protection
• Supports Detoxification Capacity

The body’s cells and organ systems depend on an adequate supply of energy to function optimally. The mitochondria, known as the powerhouse of the cell, contain nutrients and enzymes that are important for cellular energy metabolism, including those that convert food to usable energy in the form of adenosine triphosphate (ATP). ATP functions as the key source of energy for all cells. In order to increase mitochondrial output, there must be adequate fuel supply for combustion and abundant antioxidants to scavenge free radical by-products. Preserving our energy reserves and increasing energy output is a critical part of maintaining optimal health.

Lack of sleep, too much stress, poor nutrition, and prescription medications can draw on energy reserves, using them up faster than they can be replenished. Even the vital biologic systems can create an energy deficit that needs to be restored.

Clio Daily is scientifically formulated, based on published research, to boost mitochondrial reserves and recharge cellular energy production. Clio Daily includes the powerful antioxidant trio of alpha lipoic acid, N-acetyl cysteine and acetyl L-carnitine, all shown to recharge cellular energy production and the primary cellular antioxidant pools of glutathione and vitamins E and C. CLio Daily also includes key micronutrients and phytonutrients, including green tea, broccoli seed extract and resveratrol, to protect the mitochondria and continually renew the cycle of energy production.

Suggested Use:

2-4 capsules per day or as recommended by your health care professional.

Creatine is one of the most extensively researched nutrients in sports and clinical nutrition, recognized for its broad benefits beyond athletic performance. As a naturally occurring compound critical for rapid energy production, creatine supplementation has been shown to enhance strength and endurance, accelerate recovery, support cognitive performance, and promote healthy aging.

Clio Energy:

• Enhances Muscular Performance, Endurance and Recovery
• Boosts Muscle Protein Synthesis and Lean Body Mass
• Promotes Longevity and Healthy Aging
• Supports Optimal Cognitive Function

Derived from amino acids, creatine is a naturally occurring compound that plays a key role in the body’s ability to produce energy. Roughly 95% of the body’s creatine is stored in skeletal muscle tissue, with a higher concentration in fast-twitch, type II muscle fibers. Within the muscles, creatine exists in two main forms—approximately two-thirds are stored as phosphocreatine (PCr), while the remaining one-third remains as free creatine. PCr serves as a rapid energy reserve, helping regenerate adenosine triphosphate (ATP) especially during bursts of physical activity.

Creatine is produced endogenously at an amount of about 1 g per day. Synthesis predominantly occurs in the liver, kidneys, and to a lesser extent, the pancreas. The remainder of the creatine available to the body is obtained through the diet at about 1 g per day in an omnivore diet. Dietary sources of creatine include animal-based proteins, notably red meat and fish. Approximately 1–2% of intramuscular creatine is broken down and excreted through the urine each day. Supplemental creatine has been shown to enhance athletic performance and recovery, promote longevity and healthy aging, and support optimal cognitive function.

Suggested Use:

Mix 1 scoop (5 g) with 8 ounces of water or your preferred beverage per day or as recommended by your health care professional.

Clio GI Motility is a patented combination of ginger (Zingiber officinale) and artichoke leaf extract (Cynara cardunculus L.) delivered at a clinically proven dose to restore gastric motility, improve digestion, and relieve temporary gastric discomfort.

Clio GI Motility:

• Stimulates Gastric Motility and Emptying
• Promotes Cleansing of the Gut
• Supports Microbial Balance in the GI Tract

Motility in the GI tract describes the movement of food and other substances through the stomach, small intestine, large intestine and eventually out of the body. In between meals, the migrating motor complex (MMC) is a cycle of peristaltic movement that acts as an inter-digestive housekeeper of the GI tract. The MMC facilitates transport of indigestible substances and bacteria from the stomach and small intestine into the colon, inhibiting the backward migration of colonic bacteria and an overgrowth of bacteria in the small intestine. It has been shown that motility impairment typically results in small intestinal bacterial overgrowth (SIBO).

This distinctive blend of bioactives promotes contractions in the migrating motor complex, helping to restore proper motility, which ensures the steady flow of food particles and bacteria through the small intestine. In addition, it provides support for improved digestion and relief from temporary gas, bloating and associated GI discomfort.

Suggested Use:

1 capsule per day on an empty stomach, or as recommended by your health care professional.

Clio Gut is a next-generation fiber supplement designed to promote a healthy gut microbiome, support satiety and weight management and aid in healthy bowel function. Clio Gut provides 11g of fiber strategically designed for gentle digestion and optimal tolerance.

Clio Gut:

• Provides 11 g of Fiber to Support Digestive Health
• Supports Natural GLP-1 Production to Curb Appetite and Cravings
• Promotes Microbiome Balance by Increasing Akkermansia and F. prausnitzii
• Provides Gentle Relief for Occasional Constipation and Diarrhea

Dietary fiber is a critical component of human nutrition. The USDA’s Adequate Intake recommendation for fiber is 14 g per 1,000 calories. Despite its importance, only 5% of the population meets these recommendations, making inadequate fiber intake a recognized public health concern.

Adequate dietary fiber intake supports cardiovascular, gastrointestinal and metabolic health. Some examples of the digestive benefits of fiber include increased stool bulk, reduced transit time and increasing beneficial flora and microbial diversity.

Fiber is a plant-based material that cannot be digested by humans. It is classified into two main types: soluble and insoluble fiber. Certain types of soluble fiber can be selectively metabolized by gut microbiota in the digestive tract. Resistant fiber and starches pass through the small intestine and reach the large intestine where they are fermented by gut bacteria nourishing beneficial bacteria and promoting microbial diversity while insoluble fibers add bulk to stool.

Clio Gut is a next-generation fiber supplement strategically designed for gentle digestion and optimal tolerance. This innovative formula aids in promoting digestive regularity, alleviating occasional digestive distress and serving as a prebiotic to enhance microbial diversity and beneficial flora.

Suggested Use:

Mix 1 scoop (16.7 g) with 6-8 ounces of water or your preferred beverage, once daily or as recommended by your health care professional. Use with liquids below 140°F for best results.

Clio Omega Brain/ Muscle provides 820 mg of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as 50 mg of docosapentaemoic acid (DPA) per soft gel as re-esterified triglycerides, the preferred form with superior absorption. Vitamin E (as mixed tocopherols) and rosemary extract are used to ensure maximum purity and freshness.

Clio Omega Brain/Muscle:

• Supports Cardiovascular Health and Blood Sugar Metabolism
• Supports Cognitive Function and Development
• Supports Healthy Skin, Joints and Connective Tissues
• Increases Visual and Ocular Health
• Maintains Normal Inflammatory Balance

Omega-3 fatty acids are essential cornerstones of human nutrition. They are deemed “essential” because we need them for proper health but cannot produce them on our own. We must therefore consume these fats through diet or supplementation. Omega-3 fatty acids are required for a number of body functions, from proper blood flow to brain development. These long-chain fatty acids are integral components of tissues and organ systems throughout the body, including the heart, skin, joints, eyes and immune system.

Since omega-3 fatty acids are known to benefit cardiovascular health, support healthy brain function and cognition, and have also been proven to maintain normal inflammatory balance, achieving the proper balance of omega-3s has become an important health strategy, requiring supplementation for most people. The American Heart Association recommends that those concerned about blood lipids take up to 4 g of omega-3 fatty acids per day.

Clio Omega Brain/Muscle is a high-concentration fish oil sourced from waters off the Chilean coast. As the world’s least industrialized coastline, these cold, fresh waters provide the cleanest, most sustainable source of fish in the world. This exclusive fish oil is purified, vacuum distilled, and independently tested to ensure heavy metals, pesticides and polychlorinated biphenyls (PCBs) are removed to undetectable levels. With over 10,000 published studies in the last three decades, EPA and DHA from fish oil are among the most researched natural ingredients available and have a long history of safety and efficacy.

Suggested Use:

1 soft gel capsule per day or as recommended by your health care professional.

Clio Post-Op, a balanced blend of flavonoids and crucial vitamins and minerals, provides safe, long-term immune support for all populations without overstimulating the immune system.

Clio Post-Op:

• Broad-Spectrum Support for Healthy Immune Function
• Supports Healthy Respiratory Function
• Maintains Normal Inflammatory Balance

Clio Post-Op is a targeted blend of nutrients designed to provide broad-spectrum support for the body’s immune reserves. The formula includes quercetin, a powerful bioflavonoid that aids in supporting the immune system. Vitamin C and N-acetyl cysteine are potent antioxidants that promote respiratory function and support the function of quercetin. Vitamin D and zinc are important micronutrients needed to create a robust immune reserve. This powerful combination works to promote healthy respiratory and immune function in all patients, including those who are pregnant, breastfeeding or have autoimmunity.

Suggested Use:

2 capsules a day or as recommended by your health care professional.

Clio Sleep is a comprehensive formula created for patients experiencing occasional sleeplessness. Clio Sleep promotes a healthy sleep cycle by naturally boosting levels of serotonin, GABA and melatonin.

Clio Sleep:

• Formulated Specifically for Patients with Occasional Sleeplessness
• Promotes Calmness and Relaxation
• Supports Normal, Uninterrupted Sleep
• Provides Comprehensive Neurotransmitter Support

Sleep is the body’s way of metabolically and psychologically resetting itself. The body’s circadian rhythm is regulated by an internal biological clock with an approximate 24-hour cycle. In order to maintain restorative sleep, it is crucial that the brain has optimal levels of serotonin and gamma-aminobutyric acid (GABA), the relaxing and sleep-regulating neurotransmitters, as well as the sleep-regulating hormone melatonin.

The synergistic ingredients in Clio Sleep, including 5-HTP, PharmaGABA® and taurine, boost levels of the neurotransmitters and hormones that promote relaxation prior to bedtime and increase the deep, restorative stages of sleep.

Suggested Use:

4 capsules taken one to two hours before bedtime or as recommended by your health care professional.

Clio Thyroid includes a multidimensional blend of nutrients and botanicals to help maintain healthy thyroid function.

Clio Thyroid:

• Helps to Maintain Healthy Thyroid Function
• Promotes the Synthesis of Thyroid Hormones
• Helps Support Conversion of T4 to T3
• Improves Cellular Sensitivity to Thyroid Hormones
• Supports a Healthy Inflammatory and Antioxidant Balance

Clio Thyroid is a comprehensive formulation that provides a blend of nutrients and botanicals working in synergy to support thyroid health. Clio Thyroid includes L-tyrosine and iodine, which make up the backbone of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The addition of zinc, selenium, vitamin A, and the botanical guggulipid activates enzymes that enhance the conversion of T4 into the active thyroid hormone T3. Vitamin A and zinc also help improve cellular sensitivity to thyroid hormones. Turmeric, along with the antioxidants vitamin C and E and N-acetyl cysteine (NAC), provides a powerful combination of antioxidants that boost thyroid health by reducing free radical stress.

Suggested Use:

4 capsules per day or as recommended by your health care professional.

Clio V Women’s is a unique probiotic formula designed to maintain a healthy vaginal microflora and support urogenital health. A healthy vaginal environment is mildly acidic, and therefore Lactobacillus species dominate this ecosystem. Clio V provides two specific species of Lactobacilli: L. reuteri and L. rhamnosus. These two species are backed by human clinical studies to establish a healthy, stable vaginal ecosystem.

Clio V:

• Helps Maintain a Healthy Vaginal Microflora
• Supports Urogenital Tract Health
• Helps Establish a Healthy Vaginal pH and Remove Unwanted Organisms

Every area of the human body has a unique ecology and therefore a unique microbiome. The gut microbiome is spoken about frequently, but less commonly discussed are the specific microbiomes contained in other areas such as the skin, the lungs, the mouth, and even the vagina. The vaginal microbiome is abundant in Lactobacillus species, as they contribute heavily to the production of lactic acid. The lactic acid maintains a pH of 4, which if elevated, is a risk for vaginal microbiome challenges. Urogenital concerns are experienced frequently by women, and the most common interventions do little to address the state of vaginal ecology, and therefore, repeated challenges are often experienced. Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 have been studied and proven to support healthy vaginal ecology and promote microbial balance.

Suggested Use:

1 capsule per day orally or vaginally or as recommended by your health care professional.

Clio Women is a unique blend of botanicals formulated to provide targeted support for a comfortable and balanced menopausal transition.

Clio Women:

• Supports Cardiovascular and Neurologic Health
• Supports Homocysteine Balance
• Supports Healthy Arterial Function
• Maintains Normal Inflammatory Balance

The cessation of a woman’s menstrual cycle typically occurs in midlife, during the late 40s or early 50s, and signals the end of the fertile phase. For some women, the accompanying signs and effects that can occur during the transition years can be strong enough to significantly disrupt daily activities and sense of wellbeing. Clio Women contains five key ingredients each of which plays a role in supporting a woman’s unique needs during this period. Specifically, Clio Women formula addresses hormonal balance, maintains normal inflammatory balance and provides antioxidant support, as well as cardiovascular and bone support for a full spectrum of protection and menopausal symptom relief.

Suggested Use:

2 capsules per day in divided doses or as recommended by your health care professional.

Clio Women 2 is a specialized formula designed to address the diverse facets of menopause. It features rhapontic rhubarb root extract (ERR), a clinically researched ingredient renowned for its therapeutic benefits and comprehensive relief.

Clio Women 2:

• Designed to Support Women During Hormonal Transitions
• Supports Healthy Hormone Balance
• Maintains Normal Inflammatory Balance
• Supports Positive Mood

Menopause is a natural and transformative phase in a woman’s life, typically occurring in the late 40s or early 50s. Hormonal shifts, marked by a decline in estrogen and progesterone, lead to various common symptoms such as hot flashes, night sweats, mood swings, physical and mental fatigue, sexual frustration, and sleep disturbances. The onset of these symptoms commonly begins several years before menopause and persists for up to 5 years after, significantly affecting daily life and overall well being. By harnessing the researched benefits of rhapontic rhubarb root extract (ERR), Clio Women 2 specifically addresses hormone balance, maintains a normal inflammatory balance, and provides antioxidant support to help women navigate the challenges of menopause with greater ease and wellbeing.

Suggested Use:

1 capsule per day or as recommended by your health care professional.